First produced in 1880 by the Kaloyannis brothers in Constantinople, the increasingly successful business moved to the Athenian port of Piraeus in 1919. The brothers produced various styles of ouzo, but the one preferred by connoisseurs came from barrel number 12. So, as the legend goes, No. 12 Ouzo was born. It became the best-known, top-selling ouzo brand in Greece and eventually the biggest and most famous ouzo around the world.